Changing the Horizon of Endocrine Therapy Resistance
نویسنده
چکیده
7. The story of EZH2, from its discovery as a regulator of body patterning in fruit flies to the recognition of its role as a transcriptional regulator of chromatin structure and as a driver of cancer, should soon have a new chapter once clinical trials reveal whether targeting EZH2 can bring a substantial therapeutic advance. (Kim KH, Roberts CW. Targeting EZH2 in cancer. Nat Med. 2016;22(2):128-34)
منابع مشابه
The Modern Landscape of Endocrine Therapy for Premenopausal Women with Breast Cancer.
The optimal endocrine therapy for premenopausal women with early and advanced breast cancer still remains an important and controversial issue. For over 30 years, tamoxifen has been the gold standard in the adjuvant setting. New therapeutic options, such as the addition of ovarian function suppression to oral endocrine therapy (either tamoxifen or aromatase inhibitors), can improve outcomes ove...
متن کاملThe Effectiveness of Group Hope Therapy on the Time Horizon and Optimism
Article history: Received date: 28 July, 2016 Review date: 7 August, 2016 Accepted date:25 August 2016 Printed online: 1 September Purpose: The aim of the present study was to determine the effectiveness of group hope therapy on the time horizon and Optimism of divorced women aged between 25 to 40 years old in Tehran who referred to counseling centers. Materials and method: 30 ...
متن کاملThe Effects of Lumbar Stabilization Exercise Program Using Respiratory Resistance on Pain, Dysfunction, Psychosocial Factor, Respiratory Pressure in Female Patients in ’40s with Low Back Pain: Randomized Controlled Trial
Background. Middle-aged women are at risk of musculoskeletal disorders because of the decreased muscle mass and bone density caused by a decreased endocrine function. Objectives. This study investigated the effectiveness of a stabilization exercise using respiratory resistance on female patients in their 40s with low back pain. Methods. Forty-four female patients in their 40s with low back pa...
متن کاملMechanisms of endocrine resistance and novel therapeutic strategies in breast cancer.
Tamoxifen has been the mainstay of hormonal therapy in both early and advanced breast cancer patients for approximately three decades. The availability of novel compounds such as aromatase inhibitors (AIs) and fulvestrant, with different mechanism of action, is changing the scenario of endocrine treatment of postmenopausal breast cancer patients. In this review article, we have summarized the c...
متن کاملBone Health in Endocrine Diseases Associated with Androgen Excess: A Narrative Review
Introduction: Osteoporosis is humans' most common bone tissue disease that causes bone fractures. Based on the evidence, a combination of genetic and environmental factors, hormonal disorders such as estrogen deficiency, malnutrition, inflammatory factors, drugs, and physical inactivity are related to the pathogenesis of this disease. The present study aimed to review the effects of androgens a...
متن کامل